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December 2013
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Printing human tissue: moving toward 3-D printing of replacement human organs

It seems that few days  pass that I don't come upon some article or TV/web news report on topics relating to  my techno-thriller A REMEDY FOR DEATH (Playing God with Body, Soul and Bio-tech). Here are a few examples of what's turned up recently:

Example: about a week ago, the Wall Street Journal ran a  short piece  by Daniel Akst, "Tissue that's fit to print" on some  new work at Harvard (and a book describing that work) on the subject of using 3-D printing to create layers of tissue based on human cells.  The difficulty, until this work, has been in printing a vascular system to nourish the new tissue.

Another example: yesterday I was reading through Bloomberg Business Week (March 24-31, 2014) and came on Caroline Winter's article "Printing Medicine" on Andrew Hessel and his work at Autodesk, where theyare designing software that may help bring about cures for cancer . . . and who knows what beyond. Part of the work is done in conjunctioin with a startup named Organovo, which "uses bioprinting technology to manufacture human tissues" (see paragraph above).  

Sorry, at this point I am unable to find the online link to the article (I read it in my old-fashioned print copy!)  but I expect it will be up on Google or Bing before long.

BUT as I looked for it via Google and "printing medicine + bloomberg," I came upon not only pages upon pages of relevant articles, but particularly this one from a month or so ago, further making my opening point.  This, from Bloomberg  (that's only Bloomberg, not Bloomberg Business Week), I came on this article:  "3-D technology may someday print up new livers: health.)  

I'm running short of time at the moment, but plan in another post here to make the  link between my technothriller, A REMEDY FOR DEATH,  and how it integrates much of this new medical technology. (If I may modestly say so, the early drafts of REMEDY had concepts that pre-figured what we're reading now!  And there is still stuff in REMEDY that is way ahead of the curves of bio-tech, human stem-cell technology, the mystery of consciousness, neuroscience, tissue engineering , synthetic biology, regeneratiove medicine, the quest for immortality-- and the ethical and legal implications of putting all those pieces together.


Medical ethics-- "Tampering with embryos is tampering with human souls" suggests article in London Daily Telegraph

If you're on this page, you likely know that my technothriller A REMEDY FOR DEATH deals with, among other issues, questions of medical ethics, including organ and tissue regeneration, cross-species "trading" of tissues and stem cells, and the ultimate question of, When does death in fact occur?

In this blog, I've included a lot of my earlier research used in working out A REMEDY FOR DEATH, and I'm still adding new articles and studies that I find with some or a lot of relevance to the book.

Hence you may be interested in the opinion piece in London's Daily Telegraph "Tampering with embryos is tampering with souls"  by Jacob Rees-Mogg, a member of the British parliament.  The piece picks up from a debate in the House of Parliament on the issue of  "three parent embryos – or rather mitochondrial transfer".  

Mr. Rees-Mogg points out three as-yet unsettled issues with the idea of blending "parenthood" from three people:

  1. Technical: do we yet know enough about how to do this?); 
  2. Ethical (involving both medical ethics and morality: "There may be unknown consequences of tampering with the genes of an embryo, and for the unreligious there will be mental issues to be faced by those who have three parents. The gravity of the change is such that it should not be made without the most careful thought and properly tested research.)
  3. Legal:  "This is a self-evidently dangerous road to start down as although the technique cannot at this stage affect eye colour, eventually there will be therapies that will. Once this line has been crossed the argument against going further is merely a matter of degree rather than absolute. Its current aim is small, that ten children each year that might have been born should be replaced by ten different babies. This is not a major problem yet the solution is a fundamental change in our understanding of our own humanity."

I'm  not going to go further, except to add that in his bio, Mr. Rees-Mogg demonstrates exceptional wisdom and prudence by stating clearly " He is not on Twitter."  Amen to that! I say.

By the way, if you object to the word "soul" in his article, you're welcome to adopt the terms "conscious essence" within the "Vehicle" -- terms that some of the characters use  as alternatives to "soul" and "body" in A REMEDY FOR DEATH.


A Remedy for Death and "Billionaires as patrons of science"-- New York Times

"Billionaires with big ideas are privatizing American science" -- the headline of an article in the New York Times

Well, billionaires with VERY big ideas along with  a sense of elitist entitlement, and a drive for life extension (for themselves and themselves only) ,are subsidizing the fictional Hauenfelder Clinic in my technothriller,   A REMEDY FOR DEATH

Not to spoil the plot, just to say that it's about a bunch of rich old guys (yeah, just guys) who're funding a kind of Jurassic Park for  "select" humans--themselves and other elitists.  It gets into bio-tech, bio-artificial organs, organ harvesting and regeneration, regenerative medicine, and, ultimatelym,into the quest for eternal youth and immortality.

Here are some sample chapters. Hope you're intrigued!


Can brain implants help restore memory?

Restoring memory plays a key role in my scientific technothriller, A REMEDY FOR DEATH: Playing God with Body, Soul and Biotech, Though REMEDY is finished and out in the world, I still have Google search and other similar on the lookout for new developments.  (Who knows? Maybe there will be a sequel sometime. But what would I title it? SON OF REMEDY FOR DEATH?  Nah, guess I'll have to keep looking.)

Anyway, Bloomberg published the article referenced here, "Brain implants hold promise in restoring combat memory loss," which ties in (sort of) with what happens at the fictional Hauenfelder Clinic. There they use a different kind of brain implants for memory restoration.  But who knows? If there's a sequel they may adapt the approach profiled in the Bloomberg article.

Here's the link to that Bloomberg article, by Kathleen Miller:

Bloomberg: Brain implants promise restoring combat memory loss

 The research, mostly funded by DARPA (Defense Advanced Research Projects Agency) initially focuses on helping wounded soldiers with brain injuries, but is expected to be useful to others with memory disorders, such as Alzheimer's, dementia, injury or certain diseases.

A large part involves the surgical mplantation of electric probes in the brain to stimulate memories, particularly "task-based" skills-- like how to drive, how to dress and the like. This rather than --in this study-- recall of abstract memories such as names.  (But I expect work on that kind of memory restoratio isn't far behind.) 

Note, this group of studies does not involve implanting brain cells, but as I've recorded elswhere in this blog, that is being done. Link to other blog posts here on human brain cells implanted into mice, and other related

For much more, check out the   Categories / archives section on the sidebar of this blog, linking you to my past posts on memory, brain implants, tissue engineering, and more


"Scientists get closer to rejuvenating aging muscles"-- Health Day News

Rejuvenating  aging muscles -- I was really feeling the need for something like that this weekend in the course of my first-ever kayaking trip.  I felt my age then . . . NO, correction! I felt my age twice over.  But good news-- no after-effects the next day.

Which leads into an article I came upon, "Scientists get closer to rejuvenating aging muscles" by Mary Elizabeth Dallas, in Health Day News (which I had never run across before).

The report is on a study conducted at Stanford's Baxter Laboratory for Stem Cell Biology.  The study takes a very different approach than the fictional lab in my technothriller A REMEDY FOR DEATH, but I thought you'd find it of interest.

One thing struck me: "the muscle stem cells in 2-year old mice are the equivalent of those found in 80-year old humans." Implication: maybe there's a market for canes and walkers for old mice!  

Seriously, the process involves taking muscle stem cells from the oldsters (only mice, so far) and treat them in a certain way, then reimplanting in those muscle groups.  Two months later, those muscles were essentiall equivalent to those of young, uninjured mice.

Link to the article "Scientists get closer to rejuvenating aging muscles"